Name: Blackened Chicken Alfredo Lasagna Roll-Ups Recipe
Prep time: 30 min
Cook time: 35 min
Total time: 1 h 5 min
Cuisine: American
Ingredients: 12 lasagna noodle sheets; 3 chicken breasts (thighs, cutlets or tenders work too); 4 tablespoons olive oil; 2 tablespoons cajun seasoning (recipe below); 6 tablespoons butter; 6-8 large cloves garlic, minced; 2 cups heavy whipping cream; 1-2 teaspoons cajun seasoning; 1 cup grated parmesan cheese; Salt and pepper to taste; 1/2 block cream cheese, softened; 1 15 oz ricotta cheese; 12 oz frozen chopped spinach (drained well); 2-3 teaspoons cajun seasoning; Prepared chicken, diced; 1 8 oz block mozzarella, shredded (divided); 1 8 oz block colby jack cheese, shredded (divided); 2 tablespoons smoked paprika (regular paprika works too); 1 tablespoon cayenne pepper; 1 tablespoon onion powder; 2 teaspoons brown sugar; 2 teaspoons garlic powder; 1 teaspoon ground black pepper; 1 teaspoon salt; 1/2 teaspoon dried thyme; 1/2 teaspoon dried oregano; Garlic bread or Texas toast for serving

There’s something incredibly satisfying about creamy Alfredo sauce and spicy blackened chicken coming together in one dish—it’s exactly what you get with this Blackened Chicken Alfredo Lasagna Roll-Ups Recipe. The blend of bold Cajun spices with rich cheese and tender noodles makes it a showstopper meal that’s as comforting as it is flavorful.

A white rectangular dish filled with a creamy baked cheesy casserole, showing at least three layers beneath the top: a golden-browned melted cheese crust sprinkled with chopped green herbs, a thick, creamy white cheese layer visible underneath with melted strings stretching as a woman's hand lifts a portion, revealing tender pieces of meat peeking through the rich textures. The casserole sits on a white marbled surface with steam faintly rising, highlighting the fresh, gooey cheese and browned spots on top. photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Blackened Chicken Alfredo Lasagna Roll-Ups Recipe
Top Tip
How to Serve Blackened Chicken Alfredo Lasagna Roll-Ups Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Blackened Chicken Alfredo Lasagna Roll-Ups Recipe

Why You'll Love This Recipe

I have to say, this dish quickly became one of my favorites to make when I want something impressive yet totally doable. The combo of textures and flavors really hits the spot—plus, it feeds a crowd without a fuss.

Bold and Creamy: The blackened chicken adds a smoky heat that perfectly balances the silky Alfredo sauce.
Make-Ahead Friendly: You can prep these roll-ups ahead of time, making dinner night a breeze.
Vegetable Boost: Incorporating spinach keeps it fresh and adds a vibrant pop of color and nutrients.
Fun Presentation: Serving individual roll-ups feels special yet casual—a great twist on classic lasagna.

The dish shows a thick slice of three-layer lasagna on a white plate with a thin blue rim, placed on a white marbled surface. The bottom layers are waves of pale golden pasta sheets, slightly curled at the edges, with creamy white filling between them. The top layer is covered with melted, golden-brown cheese that looks slightly crispy. It is sprinkled with small pieces of green herbs and a light dusting of white grated cheese. The edges have a little browning, showing the baked texture. Photo taken with an iphone --ar 2:3 --v 7

Ingredients & Why They Work

Every ingredient in this Blackened Chicken Alfredo Lasagna Roll-Ups Recipe plays its part in layering flavors and textures. Using quality cheeses and fresh garlic makes a huge difference, and picking the right chicken cut helps keep things juicy.

Flat lay of fresh uncooked wide lasagna noodle sheets neatly stacked, three raw whole chicken breasts without packaging, a small white ceramic bowl of golden olive oil, a small white bowl filled with vibrant red smoked paprika powder, a separate small white bowl containing bright orange cayenne pepper powder, a small white bowl with pale beige onion powder, a small white bowl holding light brown granulated brown sugar, a small white bowl with off-white garlic powder, fresh sprigs of dried thyme and oregano placed side by side, a half block of smooth cream cheese, a mound of creamy white ricotta cheese, a pile of bright green chopped spinach leaves, a small white bowl filled with heavy whipping cream, a pile of freshly grated parmesan cheese, a block of white mozzarella cheese, a block of creamy yellow colby jack cheese, a few large uncracked brown eggs, a small white bowl filled with coarse salt, and a small white bowl filled with whole black peppercorns — all arranged symmetrically and balanced in proportions on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Lasagna noodles: Stick to regular lasagna sheets for easy rolling—no need for no-boil here.
Chicken breasts: I love using breasts for their tenderness, but thighs work great if you want extra flavor.
Olive oil: Perfect for searing the chicken and building flavor in your Cajun seasoning blend.
Cajun seasoning: Homemade spice mix with smoked paprika and cayenne gives that classic blackened kick.
Butter: Essential for making a velvety Alfredo sauce that coats every bite.
Garlic cloves: Fresh is best here—garlic is the soul of your Alfredo.
Heavy whipping cream: Provides richness and helps create a luscious sauce that’s not too thick or thin.
Parmesan cheese: Adds a salty, nutty punch to the sauce and filling.
Cream cheese: Gives the filling extra creaminess and pulls all the cheeses together smoothly.
Ricotta cheese: Traditional in Italian fillings, it keeps the mixture fluffy and mild.
Frozen chopped spinach: A sneaky way to add greens that won’t overpower the dish—just be sure to drain it thoroughly!
Shredded mozzarella and Colby Jack cheese: These melt beautifully and add gooey cheesiness on top.
Spices for Cajun mix: Smoked paprika, cayenne, onion powder, brown sugar, garlic powder, black pepper, salt, thyme, and oregano all bring balanced heat and depth.

📝

Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

I like to switch up the cheese blend depending on what’s in my fridge. Sometimes I’ll add a bit of sharp cheddar for extra tang, or swap spinach for kale if I’m feeling adventurous. Don’t be afraid to make it your own.

Variation: For a lighter version, swap heavy cream for half-and-half and use part-skim cheeses—you’ll still get creamy goodness with fewer calories.
Spice it up: If you love some serious heat, double the cayenne in the Cajun seasoning and add sliced jalapeños to the filling.
Make it veggie-forward: Omit chicken altogether and add sautéed mushrooms and zucchini instead for a meatless twist.

Step-by-Step: How I Make Blackened Chicken Alfredo Lasagna Roll-Ups Recipe

Step 1: Prep Your Chicken with the Blackened Cajun Seasoning

Start by mixing your homemade Cajun seasoning—trust me, making it fresh beats store-bought! Rub it all over the chicken breasts, then sear them in olive oil over medium-high heat. I usually cook mine for about 5-6 minutes per side until the outside is nice and charred but the inside stays juicy. Once done, let them rest before dicing.

Step 2: Cook the Lasagna Noodles

While the chicken cools, boil your lasagna noodles according to package instructions until al dente. Drain, lay them flat on a clean kitchen towel to avoid sticking, and set aside. This step is key so they roll up without tearing later.

Step 3: Whip Up the Creamy Alfredo Sauce

In a saucepan, melt butter and gently sauté the minced garlic until fragrant. Slowly whisk in heavy cream, and add a pinch of Cajun seasoning, then simmer a few minutes. Stir in parmesan cheese until melted and sauce thickens lightly—this sauce is your flavor bomb, so taste and adjust salt and spice!

Step 4: Make the Filling

In a bowl, combine ricotta, softened cream cheese, drained chopped spinach, diced blackened chicken, about half the shredded mozzarella and Colby Jack cheeses, and a pinch more Cajun seasoning. Mix until well combined but still fluffy.

Step 5: Roll, Fill, and Assemble

Lay a lasagna noodle flat, spoon a generous amount of filling along its length, then carefully roll it up. Repeat with remaining noodles and place each roll seam-side down in your greased baking dish. Pour Alfredo sauce evenly over the top, then sprinkle with the rest of your shredded cheeses.

Step 6: Bake and Enjoy

Bake at 375°F (190°C) for 30–35 minutes, until bubbly and the cheese on top turns golden and irresistible. Let it rest five minutes before serving—that cheese pull is worth the wait!

Top Tip

From hands-on experience, a few little tricks have made all the difference when making this Blackened Chicken Alfredo Lasagna Roll-Ups Recipe.

Perfectly Seasoned Chicken: Don't rush the seasoning step—rub the Cajun spices well and let the chicken sit for a bit if you can. It really amps up the flavor.
Don’t Overcook Noodles: Cook your lasagna sheets just until al dente; overcooked noodles tear easily when rolling, and that’s hard to fix.
Drain Spinach Well: Excess moisture in the spinach can make the filling watery, so squeeze it out or press between towels before mixing.
Allow Rest After Baking: Let your roll-ups sit for a few minutes post-oven to settle the sauce—this makes serving neater and cleaner.

How to Serve Blackened Chicken Alfredo Lasagna Roll-Ups Recipe

Blackened Chicken Alfredo - Serving Suggestion

Garnishes

I love topping these roll-ups with a sprinkle of fresh chopped parsley or basil—just a touch of green brightens up the cheesy richness. A little cracked black pepper on top never hurts either.

Side Dishes

Garlic bread or Texas toast are my go-to partners—perfect for mopping up any leftover sauce. A crisp Caesar salad or roasted veggies round out the meal beautifully.

Creative Ways to Present

For a dinner party, I arrange the roll-ups on a large platter with fresh herbs scattered around and small bowls of extra Alfredo sauce for dipping. It looks impressive but feels laid-back and inviting.

Make Ahead and Storage

Storing Leftovers

Once cooled, I cover leftovers tightly with foil or plastic wrap and refrigerate. These roll-ups keep well for up to 3-4 days—they actually taste great warmed up and almost better the next day as flavors meld.

Freezing

This recipe freezes wonderfully. I like to assemble and freeze the unbaked roll-ups in an airtight container. When you’re ready, bake directly from frozen, just add about 15 extra minutes to the bake time.

Reheating

To reheat, warm leftovers in the oven at 350°F (175°C) covered with foil for about 20 minutes, or until heated through. This keeps the sauce creamy and the cheese melty without drying out.

Frequently Asked Questions:

Can I use frozen chicken for the Blackened Chicken Alfredo Lasagna Roll-Ups Recipe?

It's best to use fresh or fully thawed chicken breasts to ensure even cooking and proper searing for the blackened spices to develop flavor. Frozen chicken can release excess moisture, making it harder to get that crispy blackened crust.

What can I substitute if I don’t have ricotta cheese?

If you don’t have ricotta, cottage cheese works well as a substitute. Just blend it in a food processor for a smoother texture. Cream cheese alone can also work, though it will be a bit denser and richer.

Can I make the Blackened Chicken Alfredo Lasagna Roll-Ups Recipe vegetarian?

Absolutely! Just skip the chicken and increase the spinach or add sautéed mushrooms, zucchini, or other veggies to the filling. The Cajun seasoning and creamy sauces keep it full of flavor even without meat.

How spicy is the Blackened Chicken Alfredo Lasagna Roll-Ups Recipe?

The recipe has a nice moderate heat from the Cajun spices that can be adjusted to your taste. If you prefer mild, reduce the cayenne pepper or omit it, and for more heat, feel free to add more. The creamy Alfredo sauce helps balance out the spice nicely.

Final Thoughts

This Blackened Chicken Alfredo Lasagna Roll-Ups Recipe is one of those meals I turn to when I want homemade comfort with a little flair. It feels fancy enough for guests but is simple enough for a weeknight win. Give it a go—I promise you’ll enjoy every creamy, spicy, cheesy bite as much as I do!