Name: Alfredo Chicken Lasagna Roll-Ups Recipe
Prep time: 15 min
Cook time: 35 min
Total time: 50 min
Cuisine: Italian-American
Ingredients: 12 uncooked lasagna noodles; 1 teaspoon salt; ⅓ cup butter; 3 cloves garlic; 1 tablespoon all-purpose flour; 1 ½ cups milk (2% or whole); 1 cup heavy whipping cream; ¾ cup parmesan cheese; ½ teaspoon salt; ¼ teaspoon ground black pepper; ⅛ teaspoon ground nutmeg (optional); 3 cups cooked shredded chicken; 2 cups shredded mozzarella cheese; 2 tablespoons chopped fresh parsley

There’s something about the rich, cheesy goodness of pasta that just speaks comfort. This Alfredo Chicken Lasagna Roll-Ups Recipe takes classic flavors you love and transforms them into portable, individual servings that are as fun to make as they are to eat. Trust me, these creamy, savory roll-ups are worth every delicious bite.

A close-up of a creamy lasagna roll held by a wooden spatula with a woman's hand, showing three visible layers of pasta and cheese sauce. The top layer is golden brown and slightly crispy with small bits of chopped green herbs sprinkled on it. The middle layer shows stretchy melted cheese sliding down, and the bottom layer is thick and smooth white cheese sauce with specks of black pepper. The background has a white marbled surface with more lasagna rolls out of focus. Photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Alfredo Chicken Lasagna Roll-Ups Recipe
Top Tip
How to Serve Alfredo Chicken Lasagna Roll-Ups Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Alfredo Chicken Lasagna Roll-Ups Recipe

Why You'll Love This Recipe

As someone who loves fuss-free meals with a wow factor, these Alfredo Chicken Lasagna Roll-Ups quickly became one of my go-to comfort dishes. They’re creamy without being too heavy, easy to prep, and perfect for feeding a crowd or keeping leftovers on hand.

Creamy and Cozy: The homemade Alfredo sauce is silky, cheesy, and so much better than store-bought versions.
Individual Portions: Rolling the noodles up makes serving a breeze—you get a perfect cheesy “package” every time.
Customizable: I’ll share some tweaks so you can make it work with what’s in your fridge or dietary needs.
Perfect for Make-Ahead: You can assemble it in advance and bake when ready—great for busy weeknights or meal prep.

A white rectangular baking dish holds six square pieces of baked layered pasta, each topped with a golden-brown melted cheese crust that has small browned spots and a few green herb sprinkles scattered across the top. The pasta layers under the cheese are soft and light yellow, with some creamy white sauce visible in between. The edges of the dish touch a white marbled surface, enhancing the baked pasta’s warm and cheesy appeal. The dish fills the frame, shown from a slightly angled top view that highlights the texture of the melted cheese and the soft pasta underneath. photo taken with an iphone --ar 2:3 --v 7

Ingredients & Why They Work

This recipe balances creamy, cheesy Alfredo sauce with tender shredded chicken and perfectly cooked lasagna noodles. Each ingredient plays a vital role in delivering that satisfying comfort food experience.

Flat lay of uncooked lasagna noodles neatly stacked, a small white bowl of golden butter cubes, three whole uncracked garlic cloves, a small white bowl of all-purpose flour, a small white bowl of creamy milk, a small white bowl of heavy whipping cream, a small white bowl filled with grated parmesan cheese, a small white bowl containing ground black pepper, a single small fresh parsley sprig, a small white bowl of shredded cooked chicken, a small white bowl of shredded mozzarella cheese, placed on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Lasagna noodles: I recommend cooking them al dente and keeping them separated in water to prevent sticking; it makes rolling them up so much easier.
Butter: The base of the Alfredo sauce that adds richness and depth.
Garlic: Sautéed just until fragrant for an aromatic punch without bitterness.
All-purpose flour: This is what thickens your sauce perfectly to coat each roll-up.
Milk & Heavy whipping cream: Combining both creates a luscious sauce that's creamy but not overly heavy.
Parmesan cheese: The star cheese that melts into the sauce, adding saltiness and umami.
Salt, pepper, nutmeg: Simple seasonings that balance and elevate the flavors, especially the nutmeg—it’s subtle but magic.
Cooked shredded chicken: A hearty protein that pairs beautifully with the smooth sauce.
Mozzarella cheese: Melts beautifully inside each roll, adding gooey texture and a mild creaminess.
Fresh parsley: A fresh green garnish that brightens up the rich dish before serving.

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Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

I love switching up the protein or cheese here depending on what I have on hand. You’ll find this recipe is a fantastic base for a ton of variations, so don’t hesitate to get creative with it.

Variation: One time, I swapped shredded chicken for cooked Italian sausage and added some sautéed spinach—totally delicious and a nice change of pace!
Dietary swap: To lighten it up, use part-skim mozzarella and whole milk instead of heavy cream—you’ll still get that creamy texture.
Veggie boost: Add mushrooms or roasted red peppers inside for extra flavor and texture.

Step-by-Step: How I Make Alfredo Chicken Lasagna Roll-Ups Recipe

Step 1: Cook and Prepare the Noodles

First, I bring a large pot of salted water to a boil and cook the lasagna noodles until just al dente. This is key because they’ll cook a bit more once baked, so you don’t want mushy noodles. After draining, I keep them separated in a bowl of room-temperature water—this little trick helps prevent them from sticking and makes rolling them later a breeze.

Step 2: Make the Creamy Alfredo Sauce

I melt the butter over medium heat, then sauté minced garlic until it smells amazing but not browned—about a minute. Next, I whisk in the flour and cook for another minute to form a roux. Slowly add milk and cream, whisking constantly to avoid lumps. Let it simmer gently for 2 minutes until thickened before stirring in parmesan, salt, pepper, and a pinch of nutmeg if you want that warm, cozy note. If it gets too thick, just splash in a bit more milk to loosen. This homemade Alfredo sauce is where the magic happens.

Step 3: Mix the Filling

I combine about 1 cup of the Alfredo sauce with shredded chicken and 1 cup of mozzarella in a bowl, seasoning lightly with salt and pepper. This mixture is going to be the creamy, cheesy heart of each roll-up.

Step 4: Assemble and Bake

With your baking dish sprayed lightly with cooking spray, I spread a thin layer of Alfredo sauce over the bottom—this stops the roll-ups from sticking. I then lay out one noodle at a time, spoon the chicken mixture evenly down the center, and roll them up like little gift packages. Place them seam side down in the pan, and scatter the remaining mozzarella and Alfredo sauce over the top. Pop it in a 375°F (190°C) oven for about 35 minutes, watching for a bubbly golden top.

Top Tip

From my kitchen to yours, these tips made all the difference when I first made these roll-ups and I want you to have the easiest, tastiest experience possible.

Prevent sticking noodles: Don’t skip the step of keeping cooked noodles in room temp water—it keeps each strip flexible and easy to roll.
Roll with confidence: Try to keep the filling on the center of the noodle to avoid spillage during rolling and baking.
Don’t overbake: Baking until the top is just bubbly and golden preserves creamy texture inside without drying out.
Make ahead: You can assemble everything, cover with foil, and refrigerate before baking the next day—super convenient!

How to Serve Alfredo Chicken Lasagna Roll-Ups Recipe

Alfredo Chicken Lasagna - Serving Suggestion

Garnishes

I love finishing these roll-ups with a sprinkle of fresh chopped parsley—it adds a lovely pop of green and a hint of freshness that balances the richness wonderfully. Sometimes I toss a little extra grated Parmesan on top right out of the oven for that extra cheesy touch.

Side Dishes

These roll-ups pair beautifully with simple sides. A fresh mixed green salad with a lemon vinaigrette cuts through the creaminess nicely. Roasted vegetables like asparagus or broccoli with a squeeze of lemon add an extra layer of texture and color to the plate.

Creative Ways to Present

For special occasions, I like to arrange each roll-up vertically like elegant little pasta towers on the plate, topped with a sprig of parsley and a drizzle of extra Alfredo sauce on the side. It makes dinner feel a bit more festive and restaurant-worthy without any extra hassle.

Make Ahead and Storage

Storing Leftovers

Leftover Alfredo Chicken Lasagna Roll-Ups store really well in an airtight container in the fridge for up to 3 days. I always let them cool to room temp before refrigerating to maintain the best texture.

Freezing

Freezing these is a game-changer for busy days. After assembling but before baking, I tightly wrap the dish with foil and plastic wrap and freeze for up to 2 months. When ready, I thaw overnight in the fridge and bake as usual—easy and convenient without compromising flavor or texture.

Reheating

When reheating leftovers, I cover the portion with foil and warm it in the oven at 350°F for about 15 minutes. This restores that fresh-baked texture better than microwaving and keeps the sauce creamy—not rubbery.

Frequently Asked Questions:

Can I use store-bought Alfredo sauce instead of making it from scratch?

You definitely can, and it will save time. However, making the Alfredo sauce from scratch gives you a fresher, creamier flavor and lets you control the seasoning. Plus, it thickens perfectly for rolling up. If you’re short on time, go for a good-quality jarred sauce and add extra garlic and parmesan to boost flavor.

What kind of chicken works best for this recipe?

Cooked and shredded chicken works best here, whether it’s rotisserie chicken, leftover roast chicken, or chicken breasts you’ve poached or grilled yourself. Just make sure it’s well shredded to mix evenly with the cheese and sauce.

Can I prepare this recipe ahead of time?

Absolutely! You can assemble the roll-ups, cover the dish tightly with foil, and refrigerate up to 24 hours before baking. This makes mealtime so much easier, especially for busy nights or entertaining guests.

What can I serve with Alfredo Chicken Lasagna Roll-Ups?

They’re wonderful alongside fresh green salads, roasted or steamed vegetables, or even a crusty garlic bread. I recommend something light and fresh to balance the creamy richness of the roll-ups.

Final Thoughts

This Alfredo Chicken Lasagna Roll-Ups Recipe has been a staple in my kitchen for those cozy nights when I want something creamy, cheesy, and satisfying without a ton of fuss. I hope you enjoy it as much as I do—feel free to make it your own, share it with friends, and savor every comforting bite.